Journal: medRxiv
Article Title: Functional Profiling of Tetraploid Astrocytes in Drug-Resistant Temporal Lobe Epilepsy
doi: 10.64898/2026.01.30.26345206
Figure Lengend Snippet: Diagram of the functions played by tetraploid astrocytes. Tetraploid astrocytes express NF1A suggesting that they are involved in electric function. Tetraploid astrocytes present SOX9, a marker of glutamate transporter function and ALDH1L1, an enzyme involved in glucose metabolism. Some of the tetraploid astrocytes have markers of reactive astrocytes (NFκB p65 and pSTAT3). Abbreviation: GLT-1: glutamate transporter 1; NADPH: Nicotinamide adenine dinucleotide phosphate; NDRG2: N-Myc Downstream-Regulated Gene 2 Protein; NF1A: Nuclear factor 1; p65: p65 subunit of nuclear factor-κβ; SOX9: SRY-related high mobility group box gene 9; pSTAT3: phosphorylated Signal Transducer and Activator of Transcription 3; 4C: tetraploid.
Article Snippet: Mouse monoclonal anti-NFκβ p65 (12054-MM04 Sino Biological, USA) and anti-pSTAT3 (sc-8059 Santa Cruz Biotechnology, USA) antibodies were both diluted 1:500.
Techniques: Marker